IF ONLY MY CHILD COULD TALK! The role of neuroinflammation in apraxia… Julie Logan, DC

IF ONLY MY CHILD COULD TALK! The role of neuroinflammation in apraxia... Julie Logan, DC

hello good afternoon well you guys are the dedicated troops sticking into the very bitter end and I I'm still stirred and moved by the last presentation I'm the mother of a vaccine injured child and I assume that many of you are also parents of vaccine injured children and it makes me angry and it makes me grieved again on all of our behalf and my talk isn't about this but this is how I got here too so let me grab my clicker here really quick and not disconnect my mic in the process I have the privilege of working with dr. Anju Osmond in our practice in Naperville Illinois and I have been there for a number of years now and I'm loving it I just want to comment on how good-looking we all are in this picture so today my talk is about a number of things but one of the big losses that we face as parents with children on the spectrum is we face the loss of this quintessential human capacity to speak and to communicate and so I know that when my son who was affected was at the age where he should be learning how to talk I didn't hear him say mommy I love you mommy I need this mommy I need that or daddy we just didn't have that like many of you have we have the Tantrums and the grunts and the crying and the everything else but though that those precious words and and really speech is what makes us human it's one of the things that separates us from other creatures on this planet so today I'm gonna talk about neuro inflammation the causes some of the treatments but really where I'm I'm narrowing and honing down to are those treatments that have been most effective in restoring verbal communication and so this is set against the backdrop of I'm assuming that you're working with a biomedical practitioner and you're addressing diet and you're addressing laboratory testing I'm not going over those things today because obviously that's what this whole weekend has been about for you so you already know that our kids many many different types of stresses oxidative stress mitochondrial dysfunction like the video clip was just about GI dysfunction poor detoxification problems with immunity and neurologic dysregulation even up to having seizure disorders and all of these things can lead to neuro inflammation so we know and you know what I could sum up a lot of this by saying you know vaccines summarize what happened to a lot of our kids but there are other things as well there are auto immunities there allergens there are microbes infections viruses some kids have injury to the central nervous system air pollution mycotoxins and all of these things again create neuro inflammation which is what leads to the symptoms the cognitive delay the lack of speech and so when we're talking about the interventions the diet and the nutrients we're talking about immune function the inflammation of a part of the body that represents itself in the cognitive delay so speech and language delay is the focus that I'm concentrating on today so neuro inflammation is chronic so when you sprain your ankle in the first minute after you've sprained it swells up to the size of a grapefruit and that's acute inflammation that's the body rushing nutrients and fluids and white blood cells and enzymatic processes to there to clean it up to heal it and it should go away but neuro inflammation is chronic it's an activation of immune cells that does not go away it's so it's unresolved and there are a lot of different cells that are implemented and implicated in this and they have different harmful actions once they've been activated and are not able to be turned off one of those is that the microglial scale which we'll get into a little bit more hair in a moment is activated and it causes the release of glutamate and glutamate causes excitation of the brain cells which interferes with the normal tasking and learning of the brain and this leads to disorder knowmia mitochondrial dysfunction and even more oxidative stress so I'm not gonna read every word on this slide but let's just say that the immune system becomes dysregulated and it's similar in analogy to if the Marine Corps started bombing San Francisco but the Coast Guard is letting foreign invaders and etc there's not protection like there should be there's self attack where there shouldn't be the whole immune system is skewed so it lets invaders in infectious agents in and doesn't fight them but yet it's spending its energy attacking our own tissues so this is immune dysregulation at its worst so this cell that is responsible for this is the microglial cell and they are if you look at this cute little picture the little triangular yellow things are the neurons themselves and this spindly pink guy is the microglial cell and you can see that they have many different processes which are those little spindly arms that that have connection with all of the neurons so all the neurons are connected to each other by these microglial cells and their job is to take out decaying dying cells to clean up plaques it's basically like the janitors of the brain in this in this regard but they also have a guerrilla warfare task force that can that can launch some pretty good artillery fire if they find pathogens so they're extremely sensitive to any kind of change in the brain because any change in the brain or infection in the brain can lead immediately to death so the main purpose of this slide this is an excerpt from an article which basically says the activation of the microglia is the hallmark of brain pathology because it causes neuronal damage and this is what's happening in our kids it's what's happening in other brain diseases and disorders as well I want to make a comment here about mast cells and this is worthy of an entire lecture of itself which I'm not going to do but mast cells are a type of white blood cell that can be in the brain it's in the entire body but when they get activated they are responsible for releasing histamine so we think of histamine accompanying allergies like the seasonal allergies or maybe some food allergies histamine is associated the anaphylactic type of reactions but when a mast cell is stimulated too often they mutate actually and they have prolonged longevity but they get very trigger-happy and so they have a decreased threshold for degranulation and in addition to histamine they also release up to 200 other prostaglandins and inflammatory mediators so this against the slide just says the same thing but one of the things I want to point out to you for those of you who have children who are dealing with pandas and pans this is very implicated in that histamines and mast cells are a big piece of pandas and pans and net didn't necessarily start off the process but it is now implicated once you have those conditions so this all leads to brain excitotoxin city and excitotoxin city is static on the line in a very damaging way so the microglial cells release their inflammatory mediators and this causes the glutamate release from neurons glutamate binds to a famous receptor called the NMDA receptor which allows calcium to get into the cells too rapidly and this causes excess excitation and even death of the neurons and this is essentially what this slide is showing so the excess calcium will actually cause injury to the cell and possibly death as well the way that this looks like in terms of symptoms of the children is hyperactivity stimming that when they're running from thing to thing and they can't focus on any one thing for more than two seconds this is them physically acting out what's going on in their brain so there are a number of things that stimulate this excitotoxin cascade one of them which we've been talking about to some degree is the immune response to infection so viral infections Lyme strep mycoplasma these these are all things that create a prolonged immune response and so then we'll have the excitotoxin cascade sometimes calcium supplemental calcium which our bodies do need but sometimes this can create a problem too because calcium is that mineral that is flowing into the cell so the way we know this is happening is when our kids become hyper when we supplement them with calcium or when their symptoms get worse but a big thing a big big thing is the food based excitotoxin so glutamates and diet so msg a means aspartate NutraSweet sometimes the amino acid glutamine but not always caffeine dyes sulfates propria nades can be in food but they're also a product of gut bacteria and sometimes phenols and and this this bottom category here we have some control over I mean we cannot always control whether our kids get sick but we can control the foods that we bring into our house and that we feed to them so this is one place where we can take control so you've heard by now if you've been to a lot of the lectures here this weekend that our kids have a lot of oxidative stress and mitochondrial dysfunction and again this could be a whole weekend seminar but the issue is if you think about putting your car into a garage and running it and closing the garage and after a while the exhaust builds up builds up builds up and there's no way for that exhaust to get out of the garage this is what's happening in oxidative stress and mitochondrial dysfunction our cells burn fuel for energy and there is a normal waste as a byproduct and part of the job of our body is to get rid of that and to handle that when we have mitochondrial dysfunction we are not able to clear out the waste from our own energy production let alone the waste from the the things that are coming into our bodies and so children with autism tend to have lower levels of those substances that help us detoxify like glutathione vitamin C vitamin E antioxidant enzymes that should be in the mitochondria and in the cell so neurons are needy neurotic um to the conclusion that neurons need a lot of things one of the things they need is they need to have a lot of antioxidant support they are very very vulnerable to oxidative stress and they are the first cells to be affected when the body is under this kind of stress so the brain consumes about 20% of the body's oxygen and it has a very high ATP requirement and that ATP is generated by the mitochondria neurons also do not make their own glutathione so if glutathione status is poor in a child the neurons are going to suffer and the neurons also have a limited ability to make their own antioxidants so it basically sets the stage for the fact that oxidative stress is going to affect the brain very strongly this is an article by dr. Rossignol basically saying that the brain regions that have these abnormalities are the ones that are implicated in speech processing behavior and etc and our children with autism so those particular regions seem to be the ones that are most affected by these conditions so dis autonomia dr. Guzman whom I work with has done a lot of work in contributing to our knowledge as a community about dis aughtta knowmia but essentially it is the loss of balance between the two arms of the autonomic nervous system fight or flight which is sympathetic and then parasympathetic which is where rest digestion reproduction learning all happen so the thing to know about this is that the autonomic nervous system is like a seesaw either one side is up and the other side is down or the reverse you cannot have both up at the same time so if a child is in fight-or-flight they will not have their parasympathetic nervous system working and this is critical because the parasympathetic nervous system is where digestion happens and it's also where learning happens so our kids get stuck in a physiologic fight-or-flight that means they have increased a release of excitatory neurotransmitters the norepinephrine epinephrine cortisol and other excitatory neurotransmitters this is another reason why we see them not able to focus tending to stem a lot bouncing around from thing to thing not able to sleep at night because these chemicals are not conducive to sleep and they're not conducive to digestion and let's face it as parents we're in the same thing if we have a child who's not sleeping and we haven't slept and well since they were born then you also as parents are also dealing with this kind of a prolonged stress response I just want to make a little a side note that the taking care of yourselves is so critical because you have to live to fight another day and another day and another day so we I'm not just talking about our kids here I'm talking about all of us in this room you're here because there's a stress in your life there's a tragedy in your life where you wouldn't be here on Memorial Day weekend so longevity is very important for us so one key point here is at the bottom that when we are in fight or flight we lose the proper function of the vagus nerve and I've included this diagram here because I want you to see just how extensive the vagus nerve is in bringing communication to the whole body the heart the lungs the entire set of digestive organs their reproductive organs all of that are regulated by the vagus nerve this is what gets shut down when we're in a stress response because when you're in a stress response your body is only concerned with surviving from one second to the next it doesn't care about what you ate for breakfast it doesn't care necessarily about proper growth or neurotransmitter production it's just trying to keep you alive but that's good for survival if you're running from a tiger but it's not good for thriving and development and continuing to grow so this is a physiologic state this is not necessarily a conscious emotional state although the two often go together so some of the signs of vagus nerve dysfunction and dissident Omiya are the Tantrums oh my lord all of us probably are familiar with the Tantrums irritability when missing meals difficulty with transitions the need for deep pressure to help regulate head banging self-injury refusing food salt seeking behavior and then huge one are the gut problems that's this constipation the SIBO small intestinal bacterial overgrowth dysbiosis the gut function is in is intricately involved with the function of the autonomic nervous system and one of the things that almost always comes in our door when we see one of your kiddos is there's something going on with the gut it's very very few who do not have some issue there and it's all related so I'm gonna get now into the therapies that we use a true health medical center to address these issues and remember I said I'm not going into all the biomedical testing and the work up and the dietary changes and all of those other things because you've gotten a big dose of that this weekend and I hope that you know you've you've had you will have some time coming up to kind of digest yourselves the information that you got so I'm not covering every single base I want to get into the the whole point of this is to talk about those things that have worked best for recovering verbal communication and our kiddos so the first thing we're going to talk about is the cell membrane repair so neuro inflammation is damage to the cell membrane and so knowing that we basically want to supply the body with the building blocks to make healthy membranes so when you have a child their job is to divide cells over and over and over again thousands and thousands millions and trillions of cells have to divide and be made every day and if they do not have the right building blocks to do this it's going to be a low-budget construction job so we don't want those kind of compromises being made when it comes to our kids and their ability to develop so the things that the cell membranes are made of is what we need to be feeding them so that is healthy fats the polyunsaturated fatty acids Omega threes saturated fats plant oils cholesterol yes cholesterol fat soluble vitamins and fat soluble antioxidants nutrients that support myelination substances that calm excitotoxin city and substances to improve cellular detoxification so we'll get into that a bit so fast our brain is made of fat our nerves are made of fat and each one of our cells has a fatty membrane around it and there is no way there's no doing this any different so fats however are very susceptible to being oxidized by neurotoxins so neurotoxins again we talked about those things like heavy metals are one of them mold toxins are another toxins from bacteria all these things can oxidize the cell membrane and when that happens it impairs the cell-to-cell communication so microglia activation like I said before the activation of these immune cells they get activated because they see defective cells being made or cells that are damaged and they're still there and so then they say well our job is to take these out the problem is there aren't enough healthy cells being made and so there are only damaged ones and we have an issue there of course so fat soluble vitamins and antioxidants are uniquely suited to pass through the blood-brain barrier and alleviate the oxidative stress in the fat portion of the brain which is the majority of it so seventy percent of the brain is made up of fat and 25% of our cholesterol resides in the brain and the myelin sheath around the nerve that allows for conduction is primarily fat so I want you to see this picture here of the cell membrane because the whole thing is made of fat and I want to call attention I think I'm not getting very good color on this screen but I think you guys have better color so you can see the light colored portion that is fat but in that in the little magnified part you can see the little yellow squiggles and those are cholesterol particles and then I want to call your attention to the purple balls that look like purple balls those are a type of fat called phospholipids and I'm going to talk a little bit more about those coming up here but those are very important so every cell membrane has this bilayer a fatty bilayer and that's why we need to be feeding our children these building blocks cholesterol is a very important and much vilified nutrient most of us are convinced as adults that cholesterol is bad for us and the lower our numbers are the better and that is just simply not true that is another construct that's been foisted upon us by drug companies who essentially want to put everybody on a statin for life or some other type of medication but it is not true in fact for adults the lower your cholesterol gets the more likely you are to have neurodegenerative diseases yourself and dementia as and other things so we are looking at more than just vaccinations when we're evaluating the standards that the healthcare system has imposed on us but the cholesterol is extremely important as a building block of the nervous system and myelin is primarily made of it and this is what makes the impulses conduct Abul so the nerve the nerves and the neurons talk to each other through nerve through electrical impulses that have to transmit like along a wire and and myelin is like the rubber coating on a cord which allows those to get through without short-circuiting and so this is what sensation thinking learning remembering all require to happen in the brain so I think this is a really important point that cholesterol was found to be the most important factor in the formation of synapses which are those links between the neurons and the way they talk to each other ha got it so cholesterol is also a precursor to the steroid hormones like estrogen progesterone testosterone etc and it's also a precursor to vitamin D so when we have low cholesterol which we tend to find in our kiddos we will also have a likely deficit of these hormones and if you are lowering your cholesterol with statin drugs you're also compromising the synthesis of these important hormones as well so additionally most of our kids have digestive and absorptive problems in the gut and cholesterol is what the body uses to make bile acids which is what enables us to absorb fats in the first place to then be used for construction purposes so this isn't just a picture of those yellow nodules on the axon of the nerve our myelin all nerves have to be coated with myelin again that's like the rubber coating on a wire it allows the the electrical impulses to pass through and it increases the speed so the damage can happen here which is going to slow down the conduction of nerves and the conduction of information from cell to cell in the brain and along the sent along the the nervous system as well that goes out to the body so this diagram I don't know if you can see but basically that top arrow is indicating that over half of our children on the spectrum when tested will show to have a low cholesterol and by low cholesterol I a number that is below 150 so we want our children to have cholesterol over 150 when it's measured and that's a minimum so these the following list of traits and characteristics is not autistic children this is the population at large so early death suicide personality disorders mood disorders imprisonment in men aggressive and violent behavior and sensory problems and language issues this is not a list of description of autism this is a description of human beings when they have low cholesterol this is one of the things that happens or this is part of the scenario that happens so more than 50% of our children are suffering from low cholesterol and we don't know this unless we test for it and then once we test for it and we see it we have some strategies so this is an article basically that states that cholesterol helps with autism hyperactivity irritability growth sleep and interactions with other people so what one of the things that we will often do because our children have impaired gut digestion and absorption is we'll actually apply a cholesterol containing substance to their skin because this is one thing that we can absorb through our skin so we'll use organic ghee for example ghee is clarified butter the milk proteins are processed and filtered out of it so the majority of people can handle it some people if you have a true milk allergy you might not be able to handle that but I would say the majority can so that's one way that we have to bypass digestion but again feeding our children healthy organic animal proteins and healthy organic eggs and other animal products as I said is a way to supply cholesterol so let's move on to the fat soluble vitamins again remember that these have an antioxidant and anti-inflammatory effect in the body but especially in the brain which is our target for today so vitamins A D and Cave these are also strongly immuno modulating so vitamin D and vitamin A are very very helpful in the fight against viruses as well as other infections when we have children who have repeated viral infections there were infections of any kind we often correlate that with the deficiency of these particular vitamins and we will immediately supply them with high dosing to correct the the immune dysregulation a special note is that viruses and pertussis can disconnect retinoid receptors in the eyes and so one of the things we'll see what they're kids is they do this sort of peripheral vision stimming or they'll look out the corner of their eye because their central vision is impaired because of this disconnection of the retinoid receptors and they actually have clear vision from the periphery and so when we use the high-dose vitamin A protocol we often see a correction in this type of stimming so the fat soluble vitamins again they're often deficient in autism because of the malabsorption issues and let's face that our kids can be extremely picky and they can be quite a bit of a stinker to try to get healthy food into them so sometimes we're dealing with many many issues here was trying to feed them well alright so remember the purple balls on that cell membrane picture this is phosphatidylcholine and you can if you recall back to the picture every single cell has a double layer of phosphatidylcholine this is responsible for membrane fluidity which is important for proper signaling of information and also the transfer of nutrients in and out of the cells we all probably at this point heard some information about methylation the Lark one of the largest consumers of methyl groups in the entire body is the manufacture of phosphatidylcholine so if we have a methylation defect and under methylated state the synthesis of this lipid is going to be compromised I mean everything that requires methylation will be compromised but if you just that's why I showed you the picture because I want you to see how important this is phosphatidylserine is another important phospholipid and it supports the function of a lot of different enzymes but it specifically quells information in sir parts of the brain particularly those parts that are responsible for learning and memory it also will break down cortisol cortisol as you know is a stress hormone now we need cortisol without it we would die but we don't want to have too much and so often as I said in that disorder knowmia State we have excess cortisol because we're in a physiologic stress response so phosphatidylserine is a phospholipid that actually breaks down the cortisol and what this does is it has a brain protective effect this also is used for ADHD the hyperactivity disorders and has been used to good effect to slow the brain down a little bit in some ways so that we enhance learning and enhance attention and focus this is also very helpful for sleep sometimes we have a dysregulation of the circadian rhythm that goes with this autonomia so our kids are or maybe even us hard to get up in the morning but don't want to go to bed at night they kind of hit that peak energy right before they're supposed to go to sleep and it's hard to get them there phosphatidylserine helps a lot with that because it breaks down these high levels of cortisol so that the body can go into sleep all right antioxidants we've probably heard a lot about these this weekend so we have vitamin E vitamin A vitamin K we have vitamin C and selenium and zinc and reduced glutathione is one of our heroes and alpha lipoic acid Co Q 10 and ADH and glutathione act together as a team on the mitochondrial level to help clean up the waste like we talked about before other antioxidants include carnitine phosphatidylcholine phosphatidylserine and then many of the plant extracts so antioxidants go around cleaning up the the intermediate metabolites that can cause damage so in the process of making energy and certain other processes there are intermediate steps that if they're not dealt with immediately can cause damage to other tissues and so the job of antioxidants is to basically deal with them before they do cause damage so I hope that we've established the need for the protection proper construction of the cell membrane using nutrients we're gonna move on now to methylation support and fully sources and this is where I get into things that are very specific to speech and verbal communication so number one the number one intervention is methyl b12 interject injections and I right now I hear all of the people who have looked at YESCO stuff going oh no oh no what about hydroxy what about adenosyl and I know it's okay but let me read this information for from dr. James new Brander who has really contributed so much to our community with his bringing all of this into our public knowledge so what he says is in his practice 94% of children have been found to respond to methyl b12 therapy executive function is improved in 90% things like awareness cognition appropriateness eye contact when called just being more like a normal kid speech and language in 80% of children this is huge there are not very many other things that have this statistical degree of success vocabulary socialization and emotion now I know very well from being in practice myself that not every child can tolerate meppel support in the same way so when I talk about methyl b12 injections this is very a very famous way of handling it the same dosing is not the right dosing for every person but understanding what your child's methylation status is and supporting it is extremely critical to this so the mechanism of action in order to explain that I want to show you the next slide let me see if I can laser so I don't know you guys can look all the way over here to your left I don't if you can see that but this first cycle is what I'm going to be talking about so that's this one over here this is a long way away the screen is so we see on that cycle if you look at the top you have methionine going down on the bottom of the circle is homocysteine now if you follow that with your eyes down you'll see down here on one of the arrows down below is glutathione and there's something in my way so I can't I can't pointer over there so this is where we're working so let me just back up a minute here to this slide so because I sedated stress is such an issue for the majority of our autistic children we have been need for that cycle that you see there on your right to keep turning because it derives the methylation reactions and there are a whole bunch of things that are contingent upon those methylation reactions happening in the brain focus attention synchronization of brain waves speech language socialization and emotion are dependent on methylation reactions occurring in the brain one of the other really important things is that homocysteine drives downward and becomes glutathione and this helps to quench those free radical reactions and it also helps with a process called trans sulfur raishin which I'm not going to get into today but it has to do with quenching free radicals reducing inflammation removing toxic chemicals and wastes from the body so again to this slide I I'm not going to be clicking back and forth too much with this slide I want to call your attention to the middle cycle there that is the full eight cycle which I'm going to be talking about in a moment and then if you move one to your left that's the bh4 cycle and if you look below that that's where neurotransmitters are made and broken down so when we enter we have to find an entry point to get in and deal with these cycles and all of these are nutrient driven so we can use nutrients to move the cycles around and if you start turning one you will be able to turn the others as well so we get in with methyl b12 usually is our first line intervention and that helps us deal with the others and then we can add in supportive nutrients for those as well so the way that if you don't already know this the way that methyl b12 is administered is usually by subcutaneous injection that is the single most effective way to do it taking it orally does not have the same effect and I wish it did it does not so the subcutaneous injection is the way to do this the dosing a standard dosing is seventy-five micrograms per kilogram of weight every three days this protocol can be modified as needed so there are some children who do better if they get it every two days there are some kids who can only tolerate it once a week or once every two weeks so we find a starting point and then we modified on the child's response it is almost painless I have given these shots to myself and every part of my body so that I could tell you where it hurts the least and that is usually in the lake or the side of the butt and looks like my pictures slid around a little bit but it is this is even though it's a vitamin it is a prescription by a compounding pharmacy because it is put into an injectable form so a pharmacy like pure compounding pharmacy in Naperville Illinois will fill that Hopkinton wellness pharmacy in other parts of the country can also fill these so there's a newer kid on the block a newer way of administering this called synapse in and synapse in is a nasal spray so if you remember from being a teenager and we were warned against you know with all the drug education sniffing drug sniffing glue sniffing gasoline was one of the surest ways to fry out your brain and so our parents and the schools I'll talk to us about this and that is because the blood-brain barrier does not exist very strongly through the olfactory nerve and through the cribriform plate when you inhale something so this is actually taking advantage of that to derive nutrients into the brain that would normally be filtered out by the blood-brain barrier before they got that far and so synapse in if you look down at the bottom it's a blend of nicotinamide right beside which is a critical for the mitochondrial function panax ginseng which is helping with brain stimulation blood flow and some of the other things with attention and stimulating neurons to be awake and alive and methyl b12 or it can also be made in hydroxy b12 depending on your methylation needs so the whole nasal delivery is being taken advantage of in a lot of neurodegenerative diseases like Alzheimer's so this is another way to do it now with the nasal spray you're not gonna get the same dosing of the methyl b12 but every now and then I'll have a family who just absolutely cannot get the shots administered whether they're dealing with a larger person who's fighting them tooth and nail and it's just not worth the danger to everybody to try to give that person a shot so this is another way of doing it now I will say if you sprayed water up your nose it would sting so this does sting a little bit but it so would water so just remember that if anyone's giving feedback that it painful if you sprayed water up your nose it would hurt too so that's the only negative feedback that I've heard from this now I'm moving on this is an excerpt from an article by dr. Frey and some of his colleagues that is talking about the combination of methyl b12 and folic acid with children with autism and again working on remember those cycles that are those wheels that are turning together so phul Inuk acid is a I'll get to the types of folic acid and fully and all of that but there is a condition that can go along with autism it's an autoimmune condition and it's called cerebral folate deficiency essentially this is where we have antibodies autoimmune antibodies that are blocking the folate receptors to get into the brain so the fully cannot get in and cannot act on this what this looks like whether a child has autism or not it's low functioning cognitive impairment mental handicapping this can go along with autism because autism is also autoimmunity in the brain so once this is identified it is very successfully treated with high dose prescription full linic acid now we don't always test for this sometimes we treat presumptively because we're talking about a B vitamin we're not talking about a drug that has a lot of collateral damage so we often test especially if we have a child who's not responding very well to some of our other interventions for speech but sometimes we just we just go ahead and give it to them anyway if they have the true autoimmune condition they're probably going to need higher doses so this article here just basically says that oral folic acid supplements led to normal cerebrospinal fluid methylation methylated folate and partial or complete clinical recovery after twelve months so there are some different forms of folic acid if you see folic acid is probably synthetic it's not a very good way of doing it it is also very inactive and there's a lot of conversion that needs to happen to make that active and we don't know whether or not the body will be able to do that the full linic acid is a non methylated active form and the reason why this is sometimes the best choice is because it doesn't tip the methylation cycle one way or another and sometimes word if we're dealing with trying to get that one right how much methylation are they under meth later do they over methylated we can use folic acid freely without having to worry about if we're adding too many methyl groups to the mix the prescription version of this is Luke Oberon and we like Luke overran quite a bit it can be compounded to get full Inuk acid over-the-counter is is easy to do but it's not very concentrated and so you end up having to give really really high doses like 25 capsules twice a day to get the dose that you could get in a tablet of luca voron so the dose for cerebral fully deficiency is one half to two milligrams per kilogram in divided doses if a child does not have CF d we may be able to use lower doses and so we essentially start out with a small amount and work our way up to see where we can get the maximal effect and then there is methylfolate sometimes you'll see it as L methylfolate this is a methylated form it is the most active form you can also get this in prescription as Depp Lynn or Sarah fullen but it does have some other things in there and can sometimes have a negative reaction to the other ingredients or sometimes to the fact that the it tips the methylation cycle over and you become over methylated rather than under methyl methyl folate is also available over the counter and thankfully you can get it in pretty high doses so if that's the best choice for your child this one does not have to be a prescription I want to talk about a product that dr. Eastman and I worked on a number of years ago and it's called motor connect and it essentially is working on a different aspect it's not working on the folate cycle or the methylation cycle but it's working on neural connectivity energy production the integrity of cell membranes and neuronal health and the part of the body specifically is the cerebellum so the cerebellum is that kind of peach colored spot in the brain it's low down and the cerebellum is primary job is to coordinate movement patterns so when you learn how to swing a bat at a baseball or drive a car or any walking talking all of these things are coordinated remember'd muscle motor programs on the ser Ellen's job is to drive that so in speech this is the coordination of our tongue our lips our vocal cords and all the muscles that are involved in doing that from a neuro motor standpoint a nerve coming to the motor cells telling the muscles what to do so the other thing is that vision and vision integrity is also very important for language integrity and language production and the cerebellum coordinates this as well so what we were finding is we're finding okay we've got kids who are having trouble with speaking they're having trouble producing the movements to produce the language and they're also having some coordination issues they've got hypotonia they have a clumsiness when they walk and we're what are what is the target of that and it's a cerebellum so this is a just an excerpt from an article benefit I mean as one of the ingredients in motor connect it's very very anti-inflammatory inhibiting a bunch of different inflammatory pathways and it also improves cerebellar function biotin is also very anti-inflammatory independently of what it does in the cerebellum but biotin dependent carboxyl aces are critical enzymes in the cerebellum for the coordination of this neuromuscular effort the other two ingredients in this are molybdenum and vitamin b6 so together usually this would come on after we've established methylation after we've established the full linic fully need and then at that point depending on what our new baseline is we would then put in the motor connect so moving on I want to talk about decreasing excitotoxin e and dis autonomia so from a prescription standpoint namenda and amantadine are two prescription medications that oppose the NMDA receptor and the glutamate mediated cascade that we talked about that leads to cellular excitotoxin City and injury there are some inhibitory amino acids l-theanine melatonin GABA and glycine Meaghan Museum blocks a calcium channel lithium orotate also inhibits the NMDA receptor and then some other things have been post teen benfotiamine also inhibit but the key thing here is to it in addition avoid excitotoxin in foods some natural agents if you look at a long list of plant extracts also help decrease the microglial activation and remember that the microglia being excited and doing their thing is what's causing the NMDA receptor to be stimulated etc etc so it's down this long pathway so talking about dis autonomia again dysautonomia is the direct result of brain inflammation and over excitation so we've talked about adaptogenic herbs to a certain extent they were on the previous slide but adrenal gland euler support is very important as well because the adrenals are responsible for cortisol epinephrine it in their own right and they need to be supported because they are being extremely taxed beta blockers I'm going to get to an alpha blockers are doing the same thing basically they inhibit the effect of the excitatory neurotransmitters we talked about namenda and amantadine and the inhibitory neurotransmitters in enemy in the amino acids chiropractic adjustments I want to talk about here for a moment because everything else we're talking about is either something they have to take or something they have to be injected with or be sprayed in their nose para practica justments are manual therapy for the neural elements in the spinal column and it is the most immediate way to change sympathetic parasympathetic balance its instantaneous so the the parasympathetic nerve tissue lives in the the cervical spine of the neck and also in the sacrum and the sympathetic tissue lives in the thoracic spine so when a chiropractor understands what they're trying to do they're trying to shift the balance which is usually to upregulate parasympathetic then they can adjust those specific areas and what I have found over years of doing this is that the kids who have chiropractic adjustments need less supplements less drugs less overall intervention than the kids that don't because again absorbing a supplement is a digestive process and it requires the vagus nerve to be working in order to even make use of all the great things that you're putting into your kid's body so that's really important and that also going under the category of up regulating that ik so I'm also gonna talk some more about acetylcholine here in just a moment so let's talk first about the propranolol so propranolol is a beta adrenergic receptor antagonist and basically what it does is it blocked the effect of epinephrine and norepinephrine in the body so it blocks those receptors it has been well studied for this use in our kids for anxiety aggression and that pathological excitation and the gray day of research has been assigned to this particular product dr. Rossignol has been so helpful to this community because he will basically rate the research supporting the interventions that we have so that we're using evidence-based medicine with the kids that we're working with this is an article basically that says that use of propranolol leads to significant improvements in cognitive performance and also improvements in emotional behavioral and autonomic dysregulation anxiety aggression and self injurious and hyper sexual behaviors this is another article you know the effect of propranolol on verbal problem-solving saying that you see down at the bottom that autistic subjects did in fact benefit from the use of propranolol so this is an option and the kids who i think of it for again those who are jumping from thing to thing can't focus can't concentrate can't subtle can't relax the kids who are in a chronic stress response this is worth a try and and it's very very safe and very non-toxic here are some adaptogens this is a list i'm not going to go through them all but again adaptogens help the body to adapt to stress so if something is too high and out of balance or something is too low and out of balance adaptogens helped to stabilize that adrenal cortex extract again that's a glandular stew arrived from animal adrenal glands probably a lot of us moms need to be using this too because if you're up with your child throughout the night and you haven't slept in years you need help as well so this is again a very safe way to help stabilize a person to help get them out of that dis aughtta knowmia state okay moving on down the homestretch we're going to get into cholinergic here so acetylcholine is very ignored neurotransmitter we think of serotonin and we think of dopamine but acetylcholine is the neurotransmitter that all of you are using right now to stay awake and listen to me and as someone I'm using to stay awake so that I can talk to you it is the learning neurotransmitter so it improves mental function memory storage and recall attention control language reasoning logic creativity it also is a neurotransmitter of the parasympathetic nervous system it acts both in the brain and in the peripheral nervous system so again it's implicated with digestion as well as with cognitive performance so increasing it can increase brain plasticity cognition and performance so galantamine is one of many things that are called nootropic so Noah topics are class of substances that improve brain function so it's kind of a general class but galantamine I'm highlighting because it has a dual function one it slows down the rate of breakdown of acetylcholine in the brain so it prolongs it prolongs the levels but it also acts as acetylcholine as well it acts on the same receptors and so this allows it to have effectiveness longer than some of the other products out there it is but it is available both as a naturally derived substance so it's pulled out from some plant extracts and it's also available as a synthetically made chemical compound the studies that I looked at showed that actually the synthetic was more effective on our kids brain performance so it's available both ways again as I said the studies that I saw demonstrated that the synthetic was actually more effective so this is a prescription it's not hard to get but it is you can get it either way here is an article that had a trial of galantamine so improvements in irritability and social withdrawal improvements in emotional lability and inattention reductions in anger and then at the bottom they got well tolerated so many of our kids have trouble tolerating some of our really good interventions we wish that they could handle and they can't so it's always a plus when something is generally well tolerated so there are a lot of other things that fit this no atrophic category because they enhance acetylcholine in the brain so here's a list it's not a comprehensive list at the bottom I've bolded a formula called get smart and that is actually a combination of naturally derived galantamine along with a number of other things on this list so the advantage of a formula is that usually they're synergistic meaning that the the elements in combination work better than one thing by itself the disadvantage of a formula is that if if someone reacts to one of the ingredients then you have to you can't use the whole thing so depending on what your doctor thinks you should do you could either start with the prescription galantamine as a single ingredient or the get smart formula as an example of a nootropic brain enhancing formula and again i mean reducing oxidative stress you've probably heard a lot of lectures this could be a weekend conference just on itself and I'm giving it one slide so heavy metals though vaccines bring in toxic metals toxic metals come in from our environment this is a big thing detoxing molds chemicals pesticides increased in glutathione levels through transdermal oral nebulizer or IV glutathione antioxidants which I showed you earlier and then things that stimulate the nrf2 anti-inflammatory pathway help to regulate the cell protective responses and CBD oil is part of that broccoli seed extract or sulfur fane or some of the commonly available ones and then balancing pH which is easily done through electrolytes and so again supporting mitochondrial function this is a quick snapshot I'm not gonna go into this I want to just take a quick moment as I'm wrapping up here to talk about what do we do when we've done all of these good things and we still have a child who doesn't talk because this is one of the greatest griefs of both us parents and us as practitioners we have a often we have a very healthy chipper child who just doesn't speak and honestly I feel like I take these kids to bed with me and my heart like I'm just processing as I'm trying to sleep like what do we need to do for these kids next because we want to crack the code for them these are some things that are the big hitters when it comes to getting our kids back removal of toxic metals is a big one and this tends to come a little bit later in the biomedical process after you've done kind of your basic stuff you've changed your diet you've done your gut dysbiosis correction you've dealt with illnesses and whatnot but this is a big game changer for a lot of our kids and I can't stress that enough and if any of you were in Pennsylvania last weekend dr. Dornfeld did a great presentation in some depth on on chelation the removal of toxic metals this can be a huge game-changer I cannot again stress that that one enough antiviral therapy for some of our children who have had chronic viral illnesses is also a game changer and so whether that's valtrex or whether that is you know non-prescription antiviral nutrients and plant botanicals antiviral therapy is can also be a big game changer when you've done all of the methylation and the nutrient support and you're not getting where you need to go chronic infections so mycoplasma Lyme strep again viruses would be in that category these are things also that can just propagate this state of neuro inflammation so that the brain is in a constant state of attack and and cognition isn't happening so dealing with chronic infections is another thing that can be the thing that cracks the code for a child mold exposure is something that I have found and it's definitely not in the majority of my families but if you have lived in water damage and there is mold in your environment in the child's environment it has to be dealt with or we will not recover them so mold is an immune confuse er it's probably lime and mold together are some of the worst things in terms of breaking somebody down and changing the immune system so the good news about mold is that once you're out of the exposure it's a lot easier to treat than line so I'm almost happy when I see this because I'm like aha I know I can deal with this we just have to get them out of the exposure and I want to put a quick plug for vision therapy the visual input is so important to brain development that if you have a child with nystagmus wandering eye lazy eye vision that's not integrated it absolutely will affect their ability to have speech development and I have had lots of good reports from parents who got their children evaluated by a developmental optometrist and got vision therapy and that not nutrient therapy but that was the thing that brought their speech in so I highly encourage you if you have not ever had your child evaluated for this that you do so because you don't want to miss it if the problem is there and then last but not least hyperbaric hyperbaric again is one of those things that tends to come a bit later in our biomedical pathway and in the whole scheme of things but it also is strongly powerful and removed in reducing neuro inflammation again quick quick excerpt from a study just talking about the effectiveness of treating children with autism and bringing their language back in so I just want to encourage you this is the the end of the whole five-day conference and you guys are the ones that held in for the last and you know all of us are here because tragedy has brought us together but also victory brings us together and it brings us back to share the things that have worked and the things that have succeeded with each other and I just I just commissioned you and bless you to go forth with all of the knowledge that you have gained this weekend I mean coming to autism one is like trying to take a sip of water from a firehose as I blast you back through the the back wall of the hotel and not every therapy that you heard about this weekend is going to be the right therapy for your child but some of them will be and that's part of the the science and the art of figuring this out is what what is gonna work for your child and that's our job and it's our privilege to partner with you guys in this so I am going to sign off now thank you so much for being here and I bless you with safe travels on your way home and I'll come back in the back and answer any questions that you might have and CSUN greet some of the familiar faces that I see in the crowd but again blessings to you guys as you go and I look forward to seeing you at another time maybe next year austat someone as well [Applause]

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