Ketone supplementation as a possible treatment for neurodegenerative diseases | Dominic D’Agostino

Ketone supplementation as a possible treatment for neurodegenerative diseases | Dominic D’Agostino


[Rhonda]: So tell us a little bit about your…some
of your more recent interests and research where you’re, sort of, been, what have you
been looking at. [Dom]: Okay, so more recently, I’d say within
the last three to five years, and it took a while to develop them, but as you know we’re
working on ketone supplementation. And the idea is to, kind of, mimic the therapeutic
effects and performance-enhancing effects of the ketogenic diet. So nutritional ketosis achieved through a
dietary means with a low-carbohydrate, high-fat diet has therapeutic effects for a broad range
of neurological disorders, in particular, seizures. And you can make the argument that pretty
much every neurological disorder is some way linked to a metabolic dysregulation. And we’re interested in understanding how
nutritional ketosis may help to preserve and, sort of, stabilize brain energy metabolism
to metabolically manage these seizure disorders. So in the process of understanding and studying
the ketogenic diet, we are developing a broad range of ketone supplements which can include
ketone esters and ketone mineral salts, which where we combine a ketone body, beta-hydroxybutyrate,
to an essential electrolyte and create a wide variety of salts. And we’re working…a lot of the work now
is focused on formulating these to make them tolerable, to make them palatable, and to
understand their therapeutic potency for different types of disorders.

4 comments

  1. Watch the full episode:
    https://www.youtube.com/watch?v=lQ7pSXIWHrI

    FoundMyFitness episode page:
    https://www.foundmyfitness.com/episodes/dominic-dagostino

    More clips from this guest:
    https://www.youtube.com/playlist?list=PLrGxo-5Uw8gKoHER5oPn–l-wvde-2bxE

  2. Interesting topic. Have heard from others (on Youtube) that exogenous ketones are not effective for weight loss , but like the idea of combating neurodegenerative diseases with supplementation. Thank you!

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