Nourish Vermont 2019 | Dr. Ted Achacoso | Who is Taking Care of your Mitochondria and Microbiota?

Nourish Vermont 2019 | Dr. Ted Achacoso | Who is Taking Care of your Mitochondria and Microbiota?



you like that didn't hear ah there's one thing I'd like to do is to warn you all there's one thing that I do in my lectures is that I swear so and the reason for this is that swearing is actually a sign of more intelligence not less before I continue I would like to thank my student Jason prale for teeing me up here he's actually tried to pull my ass here several times but david has Hollenbeck has been at it for me for a year to come and speak at your conference so thank you guys I don't know how many of you have heard about me as the guy with who was always looking for once and solutions if you know the story of the Buddha and the Guru they were walking at a bank of enlightenment River I and the Guru said to the Buddha well you know Buddha I studied for 30 years at levitation island now I can just walk on water and reach that enlightenment island and Buddha said to the Guru 30 years my god that's such a long time it's so difficult said why did you do that the ferry to enlightenment island costs only one cent all right so this is my 1 cent solution to health and is actually a Trojan horse on how do we get doctors to focus on health and not just disease right so I started this I pioneer this thing ten years are going to Philippines as proof of concept and then now we're actually going global so illness medicine when you go to an illness medicine doctor I used to be one I used to be an interventional neuroradiologist so I used to tell people I used to poke brains for a living and when you go to a doctor either you already have a flat tire right or your engine is already overheated right and it is often said that the body does not come with maintenance and warning lights well look at our dashboard in this is a the Ford Model T and the dashboard was just like this it just had an appear meter and he didn't even have a key he just said a switch right so actually the body does have maintenance and warning lights we just didn't know where to look right so now we have the technology there's a gal wing-backs Tesla but I wouldn't get it because you should measure the EMF inside a Tesla I did and we have of course the modern dashboard right and so from here we evolved because we now have the technology to this right and close up it kind of looks like this which kind of looks like the health of the musician's medicine dashboard which looks like this right so we can now measure things inside yourself like the alpha lipoic acid I am this is via urine right do I need more alpha lipoic acid do I need folic acid you know so we cannot we don't do shotgun nutrient supplementation anymore because we can measure them and so it's kind of like having your tire pressure warning that is getting low or your engine is about overheat so before you even get a flat tire or an overheated engine you already have fixed the problem alright so here's another sample of a dashboard when you are concerned with mercury and and a cadmium and this is whole blood right this is you opened the blood cell and you take a look it is not serum so one of my friends who is at the equivalent of the EPA in France the next toxin that we're going to encounter in epidemiologic amounts it's actually cadmium it was used as a rebar for for rust anti rusting rebars in the 1940s the buildings are not dilapidated and they have now leashed into our food chain right so this is another home hope dashboard you could see your your sensitivity this is not allergies so this is mine I am extremely sensitive to egg white egg yolk and Jesus and so sorry Vermont but I'm and i'm also moderately sensitive to milk but this doesn't mean that you can't make this forever you know there's an elimination phase where you can do it and after six months you can reinstitute all of these things so for example for my psoriasis and for my earth ulcer authorities patients even without testing I just advise them why don't you try removing milk and milk products from your daily meal until about six months and see what the difference in pain is and usually the pain really diminishes so as I said in in Las medicine you already go when you go to the doctor you already have a flat tire right and they diagnose like oh there's a nail in the tire right it's kind of like oh there's no more blood flowing in the left ascending or descending coronary artery this is a coronary arteriogram the blood vessels of the heart it's so how do we repair this well we can patch it we can patch the tire and there's a heart bypass surgery or cabbage that many of you know about and of course we can replace an entire tire by putting in an entire heart transplant so that's you know illness medicine diagnosis treatment so you have an overheated car when you go to a doctor well let's take your temperature may give you some antipyretics right and let's also do a culture what's causing this thing right and this is Pseudomonas aeruginosa culture for example and you're prescribed some antibiotics right so it's over and over it's like that so it's a retrospective dashboard what happened here and it's a reactive treatment you know how do we deal with this now so in medical school it's what we learned is the allopathic model or the Western model and there seems to be something missing here's how we were taught health practitioners here are also taught the same way right we're taught Anatomy structure physiology function and then very small structures is molecular biology and then what goes wrong with the body right and then we're taught about drugs pharmacology and we're taught about surgery and then we do a combination of that with minimally invasive combination procedures and when we diagnose deceased when we're dealing with pathology right what's wrong with me and when we're dealing with treatment we argue either give you drugs or surgery so in any specialty that you go this is all that we do anatomy physiology pathology pharmacology surgery over and over and over this our mantra in illness medicine so what's missing what's missing is the concept of health optimization it's as if we are actually taught that you know how to how to drive a car without knowing how to maintain it right we only know how to fix a flat tire so here in health optimization we deal with the terms detection instead of diagnosis because we're detecting levels of certain molecules like that of the temperature sensor for example and correction of all of these imbalances so this is imbalances and that's disease and that's the difference now health organization medicine then has a detection of imbalances has a prospective dashboard right what do you need and you could see here this is an actual client I call them clients because they're not sick patients are for illness medicine right so this patient this client needs alpha lipoic acid b1 b2 and it also tells you how much you need right and so we have a proactive correction of imbalances so what are the new sensors in the whole what are these new sensors in the home hope dashboard sensing no home is health optimization medicine for physicians and hope is health organization practice for non physicians because I thought that there would be more practitioners really that would be interested in the health of people because doctors are mainly interested in disease right so what are they sensing they're sensing what's called the metabolome know what's metabolome these are just small molecule my table it's like intermediates like your hormones and other signaling molecules that are found within a sample now if we take a look here this is my current fight with what we have right now this being put out there in the meteors we've become so gene-centric right we've become so DNA centric that actually the farther you get away from the gene the more you could see the effects of the physiology and environment on the individual right so that's why I chose metabolomics now most of you are familiar with the human genome database there's actually a human metabolomic data base it's maintained out of Canada and if you take a look here if you filter by metabolite status like that note those that are detected and quantified found in your urine all right and dodging asleep reduce meaning produced by your body and found in your entire cell your cell membrane you're trying to plus mu nucleus and mitochondria there are only about 820 okay this is very manageable now take a look at the metabolites autistics there are about 90 mm endogenous metabolites food metabolites account for 32,500 of them right microbial metabolites 171 drugs 2500 plant 149 toxin and pollutant metabolite 164 one of the fastest growing in the Indies in the categories and of course cosmetics and I just read an article this morning you know those who buy jewelry without checking what's made off and I see that there's also a lot of cadmium in those jewelry that you're buying so in the spirit of understanding this in the hallway on concept that we are actually made up of separate organisms you know I used to think that we were a super organism but a super organism means that you're only made of one organism that's aggregated but holoband actually means that you've aggregated with several organisms so let's tease this out in the context of the framework of health optimization listen and practice so there is exogenous metabolize meaning coming from the outside coming from the food that you eat microbes drugs plants toxins pollutants and cosmetics and then there the endogenous metabolites from four organisms and body consider your bodies having being composed only for organisms one is the anaerobic organism aerobic organism microorganism and special organism I'll explain this to you in a bit and all of them form create Network metabolites that are detectable and quantifiable note I'm actually put networked in red now the health optimization and practice proceeds from the cellular level because you know as I'd like to say to my clients you know I cannot say to your liver cell how are you today it has to open up its molecules and say this is how I am right so we have intracellular metabolites there's extracellular metabolites there's intercellular metabolites meaning communication between yourselves right so this is a sample that you already saw earlier this one has high mercury and cadmium showing that toxins can both be exogenous metabolites coming from outside and intracellular meaning inside yourself right those with dental amalgams here that has not been fixed a removed you know may be a source of high mercury levels or sometimes you want to practice in Asia just the eating fish that has a high mercury content you see this and you see that it's coming from their food so as I said I'll go through the four organisms the aerobic organism the anaerobic organism the micro organism and the special organism that produce these molecules or metabolites okay so this is what we learned about in high school the cell has a nucleus DNA cell membrane mitochondria etc this is what your kids learned in high school it's now totally different it's three dimensional and what I'd like to point out here is the presence of your mitochondria which is usually billed as the powerhouse of yourself I actually treat it more like the kitchen right it's continuously cooking your food for you and then if you don't give it a break by fasting a little bit it cannot self clean itself right and if you do say a 12 hour fast or six in our fast at night it's enough signal for it to say well okay I can reproduce now I can make more kitchens for you to code you can dirty me up again right so mitochondria are actually bacteria that reside inside your cells and they look like this I hope you haven't seen this or if you have please enjoy it again so they really look like this you have about a hundred quadrillion of them inside your cells average 500 right they are bacteria they have their own DNA they they divide by cell division there's DNA circular right they have two membranes opposed to each other and they do the they allow for example reagent medium-chain fatty acids to come in without chaperones but will not allow glucose to come in it has to be converted to pyruvate and a certain consomme so it does a lot of these things what's nice about this if we take a look at the this these are actually more gears called ATP synthase they're the ones that are actually producing the energy for you and if you look at it they actually look like they are actually classified as biological nano machines right so nature beat us to it so this is a sample of a pore and so you could see the gear turning as it as its turning it's actually putting adp and attaching a phosphate molecule to it so it's very mechanical right it has to come down and that whole thing swells and if all if your guys are familiar with gradients what is doing is just it's consuming a proton gradient right the gradient is just decreasing that's why your microtubules inside yourselves are you know we overlook those the cytoskeleton it's recently been postulated it's the one that does the quantum computations in your body because they're attached to all of the fibers in your body that's where the mitochondria actually move so don't be cowed by this light is actually very easy since we said that we they actually produce energy for us take a look if energy is actually decreasing you have immunological ceases cancer metabolic disease aging degenerative disease an easy way to remember this is that you know if you have a major city and it went on a blackout what happens right if there is no power there's a power to collect trash so your trash is left outside right there's arson and looting there's cancer you know there's accumulation of trash inside yourself you get Parkinson's disease and Alzheimer's you know so you could see that all of the systems in your body have to be powered somehow so the first two organisms that comprise us is the anaerobic organism that uses no oxygen to produce energy and the one that produces that requires oxygen to produce energy now these are actually evolutionarily two separate organisms we just happen to catch them the mitochondria that's why we evolved with a mitochondria with us plants are better they actually after catching the mitochondria they caught the chloroplast now they don't need to move to hunt for their food they just sit in the soil right so this is the caricature of that the anaerobic and energy production or called glycolysis and to break down of sugar without oxygen and then energy production which is the Krebs cycle which we all learned in high school biology right and as I like to say your mitochondria are the only organelles in your body that can actually metabolize your fatty acids to energy you know there's another organ the peroxisome that can do this but all it does is degraded so so now you know the importance of your mitochondria if you want to lose body fat so how do we do this so how do we test this remember when I was in medical school which memorize this crap you know it was it didn't have any meaning for us but now you could see inside the cell and can pass them for each of the clients that you have you know you could see the carbohydrate metabolism and it looks like this you could see their lactic acid and pyruvic acid levels and then for the an euro for the aerobic organism you could see the Krebs citric acid cycle the way it's doing if mercury is and the toxicity would see some of this actually rising or falling right so cofactors are necessary to move the pathways forward for example carbohydrates would need vitamin b1 b2 b3 lipoic acid in order to to metabolize properly so we check for the levels of those and in this client you see that vitamin b1 b2 and B 9 are severely deficient and we should supplement for those now the reason why I said network is this right if you take a look at this this is called the antioxidant regeneration pathway let's take a look at vitamin E right it regenerates everything so there was a study that failed its 80,000 men with prostate prostate cancer there's a global study and said that vitamin E and selenium doesn't work well it won't work because you know that if you enlarge the pool of vitamin E say you're scrubbing a toilet and all the rust is there right and you have to pass that sponge on to Co Q 10 if you don't enlarge the pool of coq10 of vitamin C of alpha lipoic acid then of course you'll accumulate all of your rust on vitamin E and that's why these things don't work right even and that's the thing our studies are designed even if you know these pathways we don't seem to be able to correlate them clinically before we create our protocols now the specialized organism is are those that produce hormones or cytokines and the the brain is actually produces neurotransmitters and neurotransmitters are hormones they're neurohormones right and this is of special importance again for the ones who are chronologically advanced here is my very polite way saying that you know we have people who are chronological advance so Vanille mandelic acid is is a metabolite of epinephrine home of vanilla cassidy is a metabolite of dopamine and in dollar static acid is metabolized serotonin now why is this so important is because during my time we had to open the brain to actually get the levels of these right now you can just get the levels of this in urine and correlate them with the levels in platelets and you get a more or less the same picture from the brain and why is this important dopamine is responsible for cognitive alertness norepinephrine is responsible for vigilant concentration serotonin for sensory satisfaction all of this redetermination tension intuition which determines your mood right so if you get bitchy blame it in your hormones and on your neurotransmitters and again hormones are networked right and they come from cholesterol which is a parent this is the sex hormones right cholesterol becomes pregnenolone becomes progesterone aldosterone cortisol DHEA the sauce your own estradiol DHT you can see most of this are being given up sold out of supplements right the easy way to remember this is that the way I joke my cardiologist friends is that 40 years ago we invented statins to control cholesterol 20 years later we had to invent viagra because everyone says sauce Iran was down alright so so this is now let's go to the fourth organism which is microorganism Jason Paul touched one lives a lot and so they throw out metabolites and we could see them in your urine so like for example this one died hydro phenyl propane ik acid is usually found higher in the cohort of children with autism right and then arabinose is found it is found in the in arabinose is found in the gut are usually caution OBGYNs when the patient have recurrent yeast infection as a devii don't in correction infestation if you don't correct the gut infestation that he's interesting we'll always come back right so another dashboard that we use and is this is now in the school is that we can now detect this is an actual case of a one of the powerful women in the Philippines and she didn't know she was a Salmonella carrier she had you know all the markers for intestinal bowel disease she wasn't able to metabolize fats and beneficial bacteria are down and the short chain fatty-acids was your alluded to later the butyrate etc were actually also down so we can see this now and this can be broken down so there's no more guessing right if you take a look at 78% of our bacteria actually in the gastrointestinal tract and most of them are actually found in the colon now this is what I say about this the gut microbiota is now considered as a postnatal organ meaning it grows is an organ that grows right after birth right it gets colonized when the baby passes through the vaginal canal right it's interesting mitochondria come from the mother and microbiota come from the mother now if caesarean section is done you could see that the gut microbiota of those kids are actually more epithelial the skin of the person who actually held the child first so some of my friends OBGYNs now have this technique of putting a gauze you know in the vagina if they're doing a cesarean section and then as the baby's coming out they actually wipe it in the face it could be hopefully inoculated with proper vaginal bacteria it's very important because us especially the first into three years of life by the second to third year of life is as unique as your fingerprint right so the gut microbiome changes rapidly with diet in as little as 72 hours right so I am culprit I travel to Europe and Asia all the time and of course I my gut microbiota are still asleep when I arrived in the Philippines right and I forced myself to eat so I have to deal with all of this stuff and therefore I have to effectuate my diet properly right so if it's lunch time it's lunch time there and it's midnight here my stomach's already closed then I use a broth concussion right you have to be kind to your gut microbiota so there are diseases happening in the context of microbiota for example as I mentioned autism atherosclerosis liver disease fibromyalgia poor a result a poor response to treatment for burn injury and an allergy Y allergy is because it's the gut microbiota that actually teaches the body whether or not something is foreign or not foreign friend or foe you know that's why you see people boy kids born with by cesarean section have a lot more immune problems and allergies than those that aren't right and this is the called the hygiene hypothesis so we change from Paleolithic microbiota by hygiene right and we change our immune regulation this is why now when I was a medical student the biggest immune system was a bone marrow now the biggest immune system we know is the cut right so there's a change in immune regulation from a westernized lifestyle there's a decreased microbial diversity in in living environments there's a shrinkage of microbiota diversity that's where we are and your immune system getting properly activated then you have a chronic disease and it becomes a vicious cycle right now there's the enteric microbiota got brain access when I was a medical school it was just the gut brain axis right now we know that the brain can actually modulate the behavior of my microbiota by various communication mechanisms and your microbiota can actually control your brain so who's controlling whom right it's the big question take a look at this you more and more will see news items like this microbes can play games in the mind the new light and link between gut bacteria and anxiety and then my famous report for all of those who are asking for randomized control trials for what I do is here the new hottest new cancer drugs dependin got microbes and did we tests for those before when we did the randomized control trials for other drugs no we did it right it's only now because the failure of this drug it's called ipilimumab it failed in people who lack two species of bacteria T's right so we cannot absolutely control for anything when we're doing trials and I said earlier the bacteria within our systems actually communicate to each other so your endosymbionts or your mitochondria communicate with your exes Umbreon sorry or microbiota without your conscious knowledge all right so the nut we have a network holla by aunt now and there was a Nobel Prize I was initially thinking gee if I could only prove that bacteria actually influenced the human cells directly so prokaryotic the eukaryotic communication I would do in a Nobel I was too late they actually were given up already there's an inter Kingdom crosstalk that their bacteria in your gut actually communicates with your human cells how they produce vesicles called om vs or outer membrane vesicles they contain RNA they fuse with your human cell and guess what they do they control your genome so who's in charge now right so this is the new holla beyond that I like to present so you have your human cells say yourselves your organisms 1 2 & 3 and then your view human microbiota talking to each other and then there's food so there's now a rush to find vesicles that actually control our epigenome and then of course fungi and VII and pirate viruses how they communicate with us all of this below our conscious control so the original question who really are we and perhaps were just standing here right so in summary useful and important perspective is to view the body as only have four types of cells right or actually organisms as a holiday on a gif of detectable and quantifiable Network metabolites so there's the anaerobic organism the aerobic organisms the special organism and the microorganism all of them produce Network metabolites and you put exogenous metabolites and you can get a picture of the health of a person so this was already assayed in 2011 that it will be the way to pave the way for future health care strategies now again this is the reason why I chose the metabolome right DNA can only tell you what can happen transcriptomics or RNA can tell you what appears to be happening right proteomics are the proteins the enzymes they're what makes it happen but metabolomics it what has happened and what is happening and that is what I need for the clinic's right this is what I need to show to the illness medicine doctors this is what's going on right and so let's work together you deal with the disease I'll take care to keep their healthy cells healthy right so the overarching diagram that I use is this so when you go to annulus medicine doctor you Pathology's the disease right so you probably have diabetes they will get fasting blood sugar they would get hba1c and these are called disease martyrs right this is markers and what they do is disease management so you diagnose and treat diseases right but really before the onset of disease the genetics like the nuclear DNA as as the mitochondria has its own DNA and other nucleic acids the symbiotic partners your end assembly on some mitochondria accessing by your gut microbiota your environment direct signals from environment like light EMF you know all of these signals from environment toxins you know and time every circadian time which was discussed earlier an evolutionary time which I shall discuss a bit all of this throw off metabolites right and you could now measure them you can detect the early onset of metabolic deregulations before the onset of disease remember we didn't have this dashboard before right now if you want to influence the metabolite see for example of nutrients you use the science of metabolomics you're going to hear these words more and more in the future it's actually being used heavily now well because I also go on lots of podcasts and say you got better listen to this the if you wanted influence nuclear DNA mitochondrial DNA nucleic acids right you use the science of epigenetics I shall just touch on this briefly later if you want to influence mitochondria and gut microbiota then you use the science of bioenergetics and the gut immune system just a little bit under on the epigenetic side the reason why I'm really interested in it is that I can't CRISPR cassadine myself anymore in G do gene edits and myself although I built a gene editing lab in my bathroom but but now you know that the genes can actually be influenced by epigenetic factors right to change their expression if you want to influence the direct signals and indirect signals from the environment use a science called exposomics and if you want to influence time evolutionary in circadian time then you use the sciences of evolutionary medicine and chronobiology these are the seven pillars of health optimization metabolomics epigenetics by energetics cut immune system exposomics chronobiology and evolutionary medicine and guess what these were all the lifestyle factors that we discussed earlier except now I can measure them right so that what's epigenetics really you're hearing about it and you'll be probably heard about it these are heritable changes in gene function that do not involve any change in DNA sequence this is my favorite slide of epigenetics so a woman who smokes while pregnant induces epigenetic changes in three generations all at once herself her unborn unborn daughter and her daughter's reproductives and born daughter's reproductive cells right and these are not genetic changes these are just changes in gene expression that are heritable so I caution women who want to get pregnant is to actually you know clean their epigenetics the up otherwise you know so time had this old issue with DNA it's not your destiny and this is my quarrel because when you're with DNA it's very dramatic right you either have one red one blue eye and one black eye the structural changes are very dramatic or the functional changes are very dramatic you lack one enzyme and suddenly you you are unable to grow but what about us you know how can we influence our genes for health when look with food we can do it look with food we can take food that are rich in folic acid and beta Ian and choline and B vitamins and then those methyl groups you know that they call methyl groups they can attach themselves to the what's called the histones or is the apparatus that is involved in reading the genes right they can attach themselves there and say from this point of methyl marking to that point of methyl marking do not express this and that happens to be usually a cancer gene so let's take a look at some foods that do that I'd like to focus on for example you tell your kids eat your broccoli and that's because it Isetta lates things it activates anti-cancer genes right or eat more garlic never mind the kiss just eat your garlic and you will have its anti-cancer benefits now let's take a look at exposomics right many people just thinks of toxins separately but it's actually all part of the exposome exposome is everything that you've been exposed to in utero from when you were in conception all the way up to your current age so if your mother was drinking during the time of pregnancy then this is part of the exposomics right then you have all the x-rays all the MRIs and everything else and then we take a look at your health outcomes your your exposure to antibiotics you know your exposure to all of these substances or all part of exposomics and this is you probably like this light the exposome is the internal and external equivalent of your genome right so if you look at this slide you see that there's a backhoe computer consumer products physical activity diet water and then your environment your green spaces etc would affect your internal environment or yourself transcriptomics proteomics metabolomics which were measuring and then you can determine their health risk and impact right so this is a easier way to remember it so your genome plus your exposome your environmental genome and your lifestyle and if you don't know this lifestyle is now called the behavioral so determine your health which is comprised of illness and well-being right if anyone of you is interested there is an the World Health Organization maintains an X plus um Explorer take a look at all the toxins that are available out there and use this geared towards cancer but you might find a few things that are interesting right so chronobiology this was discussed earlier also so chronobiology is about how do we adapt to the 24-hour life cycle right to discuss the sun cycle where yolk to the sun as people like to say we wake up with it and then so here's how I look at the role of chronobiology you know that it's already actually been involved in studies and obesity right Jason man said I mentioned earlier that about Nobel Prizes were given out in 2017 for a condo biology finally right and what I hate the most is when people tell me I should wake up early in the morning so I will be more productive no there's different chronic types you know this is a work from Michael Bruce if you're a dolphin you usually diagnosed as an insomniac because you sleep in one eye open so it's sensory right if you're a lion you have so much energy and morning you peter out in the afternoon kind of like you know some lovers if you're a bear if you're a bear you know you basically follow the Sun and if you're a wolf you hunt in packs at night so you're more awake at night so you have your own Khurana type and your schedule should be dependent on that so there's no one-size-fits-all in terms of what your schedule should be right so let's take a look at evolutionary medicine or Darwinian medicine and this is a sad slide for me to present why because it says that health is not selections goal selection maximizes reproductive success so you are not wired to be happy guys you are wired for reproductive success so you have to work on your happiness so the main takeaway here is that the world that we've created our bodies are no longer adapted to that world right so here there's a genome environment mismatch and in in the industrial age and now in the Information Age now there was an interview with a guy who arted the Paleo diet this is why paleo diet would works for some people right you're moving them back into the paleo era and it was not Loren Cordain actually it was s Ethan Boyd who started it I'm old enough to have his original book called Paleolithic prescriptions and I was actively teaching at George Washington vs. School of Medicine then and I was fascinated by the fact that his desire Studies on the vanishing tribes around the world and he compiled them in a book he said if you want to eat paleo Ted he said you have to eliminate all people in the world and leave only 800,000 people and then maybe you could eat paleo again so that was a sobering comment so my perspective this is this metal evolutionary medicine asks why do we get sick health optimization medicine asks why do we get healthy right so illness medicine diagnosis entry CC's health optimization medicine and practice and attacks and correct imbalances currently the imbalances are corrected at the level of the metabolome for example nutrients and hormones if someone can have a quantum device for me to prove that energy healing works for detection and correction it would be an easier sell to illness medicine right so this is a Trojan horse for me to say hey let's start thinking about health so what is health really I give this in all my lectures it's a but if you if you come away from this lecture just remembering this I would be very happy but external happiness right I'm dependent on you to memorize this so health is an optimal physiologic state characterized by a the absence of disease and the maintenance of be balanced between anabolism meaning processes that make things grow and catabolism processes to destroy things according to the cycle of life of an organism right I had to converse I was a heavy conversation with my student there Roland out today and I said so she said dr. Ted what are what are demons I said they're catabolic angels right so you could think of it that way right so absence of disease is illness medicine and health optimization medicine is about maintenance of the balance between your anabolic and catabolic states according to your cycle of life it means that just because you're not sick doesn't mean you're well it only means you're not sick right now people confuse health food fitness fitness is a different definition right it's an optimal physiologic state that allows one to handle stress physical emotional mental from a baseline state according to the cycle of life of an organism take a look at the advertisement of Viagra he says it doesn't say make sure that you're healthy enough for sex it says make sure that you are fit enough for sex right in other words you have to do vanilla before you can become a porn star so so it means being physically emotionally mentally fit ask the question fit for what for the legally minded ones here is that you ask whether a person is fit enough for trial right mentally fit enough for trial not healthy so now that's health and fitness now optimization they organize your metabolic sub-networks the values that it had when you were 21 to 30 years old which is called optimal range now neoteny is the subject of making things grow younger all right and I love the term and the range by which if you come to me off range and what is that optimal range really so Hertog who I trained under the mean value at age 25 plus minus two standard deviations so when I do hormone balancing in Paris year twenty five years old Gordon range is American his a median value between age twenty to thirty and my range is this we take the 50th 75th percentile at age 21 to 30 or we use evolutionarily derived values such as that for the hormone vitamin B right but I mean this is not really a vitamin is a hormone so and and I I say this about vitamin DS because it's very common error that people think that just because you're not getting rickets or nutritional Oscar Malaysia doesn't mean that you don't need vitamin D right the vitamin D of the Masai tribes or the Maasai tribes is actually about 50 between fifty nine hundred and I'll let you in on a little secret if I see my clients values rise over 50 most of their diseases actually become go in the background it's easier to manage them right so this means that home hope does not use illness medicine range of values the RDA values are known as survival values they are not optimal values so medicine so how do I after doing the diagnosis the the the detection how do I correct this my first line is using bioidentical and bio actives for example by identical hormones bioactive nutrients by acting nutrients for example instead of using folic acid I use methyl that are hydrofluoric so I don't have to use like for enzymes to cut it down turns out that 40 percent of the world population actually has as lazy lazy enzyme and one of them right I used to get clinical metabolomic testing of my vitamin b9 and I had to supplement all the time because it's always low right and then I got a genetic test and sure enough my my reductase enzyme was actually very lazy and I said well whether or not you get a genetic test or you get a matter of metabolomic test you're gonna do the same thing right you need to do the supplementation the second line is fighting City calls Windy City calls bacteria and fascists and the third line are Cinna biotics or the drugs finally that never been encountered in the body in evolution now when I was starting this pioneering this it was very funny doctors would call me up he said dr. Ted you know I want to know how your nutrients and hormones are going to affect my drug therapy for your poor my patient and I go well you got this all backwards I said the nutrients and hormones have been seen by the clients by the patient's body during evolution your drug has never been seen by by the body in evolution so you tell me how your drug therapy is going to affect my nutrient and hormone therapy and they go so my challenge to nourish Vermont is this given the results of a clinical metabolomics test provide a 90 day bespoke menu that makes food part of the first line of correcting borderline deficiencies and subtle toxicities instead of just using supplements for example if and I used to insult other doctors this way data they because they used to say that don't take those supplements given by dr. Ted you know you can just eat them so they're useless and I asked them ok give me a source of food that's rich in alpha lipoic acid and they go right give me a source of food rich in Co Q 10 and ago and so you can shut up right so so here's the here's it's really very simple measure the levels of metabolites compared to optimal ranges and balance using network Y doing chips ping so much of the errors that we have seen in the past like for example in anti-aging medicine in hormones is that we were shifting one hormone at a time we were not looking at the entire network so if you shift one you have to shift the entire sub Network right as you saw in that anti oxygen antioxidant or generation pathways so in the sex hormone pathway so the clinical practice of health organization medicine is really very simple the science measured the metabolite levels especially the nutrient and hormone networks right the art is to balance the nutrient hormone networks to the metabolite levels found that ages 21 to 30 years old and because many of the clients sometimes come back from the illness medicine doctor says my thyroid hormone is normal and you go do you know how I ask the doctors do you know how that has been derived it's been derived from a thousand cases ages three to ninety four and averaged out and I am 57 years old and what am I doing with that range right so I'm also as sheets can tell you know this has been a 10-year experience for me pioneering in something is your is this framework evidence-based and you know that evidence-based medicine is actually on the decline this was wonderfully assayed in 2011 also because there's a rise of pens person-centered clinical medicine right it's now geared towards individual the illness medicine doctors of course you have your antibiotic has to work across populations right but how health is unique to the lifestyle the genetics and everything else exposomics and everything else of each individual so you cannot actually say oh that thing will work for this one right it's not generalize generalizable so I made a little health wrench to remember this so health is an optimal physiologic state characterized by aid absence of disease and here we have allopathic medicine which is Western medicine alternative medicine complementary medicine integrative medicine and functional medicine now let's flip that over and when you're detecting borderline deficiencies and subtle toxicities according to the cycle of life in the organism you are now in the realm of Health Organization medicine so illness medicine uses quantitative statistics right so you see all those beautiful charts that are shown to you by Jason earlier we use qualitative statistics we use case reports right would they use evidence-based illness medicine or they call themselves evidence-based medicine but I usually say it's evidence-based illness medicine is only applicable to that area right and we use evidence informed medicine right and the way I do this in Asia is to remind doctors as an if you patient asks because they're very Catholic they're right if a patient asked for oh sorry are you going to ask for a randomized control trial that's going to help your patient you don't you just give it so so if what's a functional test you hear about function all the time functional class is really very easy say for example there is a molecule that has to transform from A to D and from A to B there needs to be a cofactor or say a vitamin or a mineral that's in there right and so if there is no mineral in there you see that a will start to rise because it cannot move forward so there's a simple functional test now this is exemplified by pH f is vitamin b9 right falling so if you see for me me know glutamate levels rising it means that you lack vitamin b9 that's the simple meaning of a functional test right so please don't confuse us with functional medicine because that's been the question it's we are not after the root causes of disease right we are only after the maintenance here of your anabolic and catabolic balance according to your life cycle right so let's get back to this ranch again so yellowest medicine diagnosis and treat disease health optimization medicine defects and correct imbalances illness medicine uses disease management we use health management right illness medicine is after lifespan health organization medicine is after health span so now you can see the difference right so let me tell you this story about us and Tiffany's I hope you haven't heard it yet so please is that yo sister goddess of dawn right and givenness was the son of the king of Troy he's mortal right so please see us pleaded let me beloved diffidence live forever her eyes filled with tears her skin flushed and even Zeus was moved so he granted her request business was now immortal descendants would live forever but even as Zeus didn't have the power to make him a god and so as time passed if Venus like all mortals began to age first years noticed the wrinkles upon his brow and as the years passed his muscles began to grow weak his arms and legs grew slender his hair grew gray then even the light of his beloved ears no longer gave him strength it ones head CEO Scott Baird is no longer and so she used her powers to transform this shell of a man into a cicada she watched as they emerge from the ground his body pale but fresh as she shed his old skin wings spreading once there were arms and that voice singing on and on and on and what was he singing I want a guy right so moral of the story if you ask for immortality don't forget for eternal youth right illness medicine asks for mortality if you take a look at all their lifestyle recommendations I'm dealing with the cardiologist and archaeologists you know all at the same time and they all have their lifestyle recommendations what's the endpoint to prolong your life well that if I'm in pain right so health organization medicine asks for eternal youth which is health and vitality so I just like to end with that and give you a few updates of what I've done so far and after those 10 years so we now have developed an online training course in health organization medicine and practice we just launches this February and it's now available worldwide it's at the Health Organization that org website the first for the physicians here the first course clinical metabolomics we were able to get 45 CME credits EA this is to encourage doctors actually take it this is how it looks like as quickly there are there will be the seven modules which are the seven pillars a clinical metabolomics or a biology exposomics epigenetics evolutionary biology biotechs and cat immune system so right now we only have the clinical metabolomics up we hope to have all the other modules by the end of the year if there are any experts here who would like to help us with content or donate their content to us we'd be very happy our website has a free the free introductory module for those who are unable to watch this presentation for example there is a comprehensive a presentation at health documentation medicine at org which comes as a free module if you register we just got our say this dude Dave earlier that we just got our nonprofit status this February 20th and our history began in the Philippines I formalized the clinic there five years ago and it's proof of concept that it is a clinical framework that works and it's financially viable model for physicians and practitioners because you have to take a look at how much they will earn right so it looks like this the clinic is by balance the detection of imbalances is actually done here in the United States by Genova Diagnostics is out of North Carolina they're one of the largest purveyors there are less than ten commercial fully commercial large clinical metabolomics labs in the world and I'll show you what I did and then we did do correction of imbalances actually all of these supplements are actually made here in Vermont and they're flown by air to Manila and if you could see here this is actually custom dosed for you so you could see the packs contain morning noon and evening and it will be different for anywhere for everyone if you don't need vitamin C there's none if you don't need omega-3 there's none I was telling someone earlier that one of the things that we're seeing now since doctors are over prescribing omega-3 then they're upsetting the omega-3 omega-6 balance and so we see there make six levels really pulling down the we are now working with biodynamic farmers to provide bespoke nutrition so essentially this is a Beyond Organic diet that Roland I did in Manila just a couple of months ago and essentially they took a look at their they took their own lab tests and they we discussed with them okay how do we provide a 90 day menu now for all of this especially those who don't like to take supplements right so that's projects now ongoing it's my challenge to you guys if we could do something like that and perhaps a cookbook on how you mix and match things together based on your test results I've been training people for a long time these are now all double boarded board certified out of Europe and I actually pushed four years ago for the building of the first commercial metabolomics laboratory for use by the ASEAN countries yay so we soft opened last year in June and we are going to be fully operational in terms of all the services that offers by the end of this year so it needs these kinds so I use my energy to actually push this kind of development in the ASEAN regions the other thing that I'm doing is to make health optimization that is in a fellowship within the Philippine Medical Association if we are able to do that then we could cross pollinate across the 10 ASEAN countries because we have no baggage right so it could be adopted as our fellowships also in the other countries and then United States will be left behind so we maintain an active presence in the world mitochondrial society and the International Society of microbiota in Europe because all the research here is mostly really basic research and there they're doing fecal microbiota transplant they're doing all of these things that have already been there for a while so we're going global and we're proud to have pioneered health organization medicine and practice in the Philippines now with a my student has actually started his clinic in Canada in health organization practice we are grateful to for your help in keeping health organization medicine on track to become a medical specialty and not only the Philippines but in NECN countries but worldwide now this is what I usually get us about you know so what's your prescription for great health the prescription for optimal health is very simple its sleep well eat well hydrate well breathe well move well son well ground well relate well and love well right and then I a gave of all things sexual health optimization medicine lecture at the Royal Society of Medicine last year and someone pointed out it lacks think this is a sexual health optimization medicine lecture well don't blink thank you yes sir the question was do my patients have to be maintained forever for for those who are thirty and younger usually after about three to six months of therapy of balancing they usually are able to produce their hormones on their own and everything else after 30 the hormone levels go down right and so we have to address those things now coming in and also with the findings right now that we have increased number of toxins in our systems and so forth right so so now they go on long term monitoring the the key is really this I I like setting the disease on the side like for example there was this nineteen year old who came to me the mother was a physician and had bipolar disorder and he had his own psychiatrists I see psychiatrists nume was my professor in psychiatry right and I said this is what I'm gonna do so I balanced his hormones a new chance and lo and behold you know you see his growth hormone levels really really weighed down there for a for a nineteen-year-old not producing enough testosterone and so on from 240 pounds in in when he was 21 he was down to 130 from no no school to school and this is not paying attention to the diagnosis this is just keeping his cells healthy so I that's why I don't twirl the ls medicine have no claims I just want to keep yourself healthy so the proof is when you're balanced then you can be maintained you know when you're younger when you're older you need a little bit more follow-up yes sir the the question was about the micro microbiome and how do we maintain it my thing that I usually say is that the fastest the fastest disappearing nutrient in our diet is really fiber right and we need about an average of 34 grams of fiber daily and we barely meet that and fiber is actually the food of your microbiota so if you rotate your fibers around you could actually generate healthy microbiota right in the recent studies now if they even show that well probiotics will help but they will only initially colonize it only to allow your native bacteria to grow again right so those are the new new findings that are going on so for me it's actually you know a rotation of your plant-based diet a lot of I get questions all the time you know is vegetarianism good for you you know I I advise them to do visitor to be a complete vegan for two weeks every three months just to induce Hermetic stress in the system cleans you out and then you can be an omnivore over again right so these are practical things that you keep in mind because in the influence of the micro bio microbiota which you're saying if your gut is there you know you must give it a proper food and care yes yeah yeah you know the thing about methylation is just so isolated portion of biochemistry that is actually there's a methylation cycle in here you know there's the the urea cycle in here there's a beach for cycle in here and everyone's just looking here look all the way down right before you even look at this look at where it's all coming from right and that's why I usually remain quiet about you know when when people just focus on one area of biochemistry versus another because those are all Network look at the biochemical Network I think biochemistry is now being taught in what's called motifs right you can take a look at the motifs actually in in in the in the chemistry and say no actually it's more of a problem here rather than a strict methylation problem right and that's that's what that's how I look at things rather than looking at these in isolation because when you look at things in isolation you're going to make a mistake because you don't know where it's related to right yes sir there is a set of guidelines that is going to be given you that you have to start three days before the testing including the amount of water you drink you know the foods that you can take and so on so that your urine will actually contain more or less representative amounts of neurotransmitters yes ma'am you can go to health musician medicine org and you can email us I probably will be the one to answer you know actually some answer is it and it is usually passed on to me where unfortunately we're moving our current learning management system into a new one so but you can just go there and and and inquire and we could give you the people to network with right but what we lack now are actually people who will actually translate this the food yes people with sorry people with end-stage renal renal disease what I do instead of saying they can't take fiber they cannot take fiber let's measure that's the whole point here is that we can measure you know what their kidneys can take what they cannot take we can take a look at the imbalance there was a quarrel that I had for example which is more severe than this in in in Europe because he was saying you know you don't take supplements when you have cancer and I said the finding was in mice of course but I said but what if you can measure them and turns out that he didn't know that you could measure this now so instead of that we could take a look at your fiber requirement and then we could devise a fiber a type of fiber mix for you that your body can't and kidneys can tolerate I think you're letting me go thank you you [Applause]

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